In the Caribbean region, a high prevalence of vector-borne diseases and frequent cross-border travel challenge these small nations’ abilities to prevent, detect, and respond to global health threats. A single outbreak can have devastating effects on such countries, and can easily and immediately spread from one country to another. At the upcoming Caribbean Community (CARICOM) Conference of the Heads of Government meeting this summer, leaders of CARICOM Member States will consider strengthening the region’s ability to tackle this important issue through the means of a five-year regionally coordinated global health security roadmap.